Abstract | BACKGROUND: METHODS: There were 85 patients as cases who presented with first-time hemorrhagic stroke that were assessed within 6h after the incident. The control group consisted of 85 healthy volunteers. HG was defined as hematoma enlargement >33% at 24h. END was defined as an increase of ≥ 4 points in National Institute of Health Stroke Scale score at 24h from symptoms onset. Plasma visfatin levels were determined using enzyme immunoassay. RESULTS: Plasma visfatin levels were significantly higher in patients compared to controls. Plasma visfatin level emerged as an independent predictor of HG [odds ratio (OR), 1.154; 95% confidence interval (CI), 1.046-3.108; P=0.009] and END (OR, 1.195; 95% CI, 1.073-3.516; P=0.005). For predicting HG, area under curve (AUC) of plasma visfatin level (0.814; 95% CI: 0.715-0.890) was similar to that of hematoma volume (0.839; 95% CI, 0.743-0.909) (P=0.703). For predicting END, AUC of plasma visfatin level (0.828; 95% CI: 0.730-0.901) was similar to that of hematoma volume (0.863; 95% CI, 0.771-0.928) (P=0.605). Visfatin did not improve AUC of hematoma volume for predicting HG and END (both P>0.05). CONCLUSION:
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Authors | Shui-Jun Gu, Hong-Fei Xuan, Ming Lu, Xin-Zhi Chen, Wei-Feng Dong, Xiao-Feng Yan, Yun Si, Guo-Liang Gao, Dian-Xiang Hu, Jian-Qing Miao |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 425
Pg. 85-9
(Oct 21 2013)
ISSN: 1873-3492 [Electronic] Netherlands |
PMID | 23916712
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- Cytokines
- Nicotinamide Phosphoribosyltransferase
- nicotinamide phosphoribosyltransferase, human
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Topics |
- Aged
- Area Under Curve
- Basal Ganglia Hemorrhage
(blood, diagnosis, physiopathology)
- Biomarkers
(blood)
- Case-Control Studies
- Cognitive Dysfunction
(blood, diagnosis, physiopathology)
- Cytokines
(blood, genetics)
- Female
- Gene Expression
- Hematoma
(blood, diagnosis, physiopathology)
- Hospitalization
- Humans
- Male
- Middle Aged
- Nicotinamide Phosphoribosyltransferase
(blood, genetics)
- Prognosis
- ROC Curve
- Time Factors
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