HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of Urtica dioica on memory dysfunction and hypoalgesia in an experimental model of diabetic neuropathy.

Abstract
Diabetic neuropathy is considered as a disease of the peripheral nervous system, but recent evidences suggest the involvement of central nervous system as well. In this study we evaluated the effect of Urtica dioica (UD) extract against memory dysfunction and hypoalgesia on a mouse model of streptozotocin (STZ) induced diabetic neuropathy. STZ (50 mg/kg, i.p. consecutively for 5 days) was used to induce diabetes, followed by treatment with the UD extract (50 mg/kg, oral) and rosiglitazone (5 mg/kg, oral) for 8 weeks. Cognitive functions were evaluated using Morris water maze and passive avoidance step through task. Pain thresholds were measured using thermal, mechanical and chemical induced hyperalgesia. We observed that chronic diabetes resulted in a decline in circulating insulin level, elevated blood glucose, reduced body weight, increased water intake, cognitive impairment and hypoalgesia. UD significantly reduced the blood glucose and polydypsia, as well as improved the body weight, insulin level, cognition and insensate neuropathy. In conclusion, UD showed results comparable to rosiglitazone in reversing the long standing diabetes induced complications such as central and peripheral neuronal dysfunction.
AuthorsSita Sharan Patel, M Udayabanu
JournalNeuroscience letters (Neurosci Lett) Vol. 552 Pg. 114-9 (Sep 27 2013) ISSN: 1872-7972 [Electronic] Ireland
PMID23916662 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Blood Glucose
  • Insulin
  • Plant Extracts
  • Thiazolidinediones
  • Rosiglitazone
  • Streptozocin
Topics
  • Animals
  • Avoidance Learning (drug effects)
  • Blood Glucose (drug effects)
  • Body Weight (drug effects)
  • Diabetic Neuropathies (chemically induced, complications, drug therapy)
  • Drug Therapy, Combination
  • Insulin (blood)
  • Maze Learning (drug effects)
  • Memory Disorders (complications, drug therapy)
  • Mice
  • Pain Threshold (drug effects)
  • Phytotherapy
  • Plant Extracts (administration & dosage, chemistry, pharmacology, therapeutic use)
  • Plant Leaves (chemistry)
  • Polydipsia (complications, drug therapy)
  • Rosiglitazone
  • Streptozocin
  • Thiazolidinediones (administration & dosage, therapeutic use)
  • Urtica dioica

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: