Parasympathetic activation by pyridostigmine on chemoreflex sensitivity in heart-failure rats.

Abstract

We evaluated the effects of parasympathetic activation by pyridostigmine (PYR) on chemoreflex sensitivity in a rat model of heart failure (HF rats). HF rats demonstrated higher pulmonary ventilation (PV), which was not affected by PYR. When HF and control rats treated or untreated with PYR were exposed to 15% O2, all groups exhibited prompt increases in respiratory frequency (RF), tidal volume (TV) and PV. When HF rats were exposed to 10% O2 they showed greater PV response which was prevented by PYR. The hypercapnia triggered by either 5% CO2 or 10% CO2 promoted greater RF and PV responses in HF rats. PYR blunted the RF response in HF rats but did not affect the PV response. In conclusion, PYR prevented increased peripheral chemoreflex sensitivity, partially blunted central chemoreflex sensitivity and did not affect basal PV in HF rats.

• Authors: João Paulo J Sabino, Carlos Alberto Aguiar da Silva, Humberto Giusti, Mogens Lesner Glass, Helio C Salgado, Rubens Fazan Jr
• Journal: Autonomic neuroscience : basic & clinical (Auton Neurosci) Vol. 179 Issue 1-2 Pg. 43-8 (Dec 2013) ISSN: 1872-7484 [Electronic] Netherlands
• PMID: 23911533 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013.

Chemical References

• Cholinesterase Inhibitors
• Pyridostigmine Bromide

Topics

• Animals
• Cholinesterase Inhibitors (pharmacology)
• Disease Models, Animal
• Heart Failure (physiopathology)
• Heart Rate (drug effects)
• Hypercapnia (physiopathology)
• Hypoxia (physiopathology)
• Male
• Parasympathetic Nervous System (drug effects, physiology)
• Pulmonary Ventilation (drug effects)
• Pyridostigmine Bromide (pharmacology)
• Rats
• Rats, Wistar