Abstract | BACKGROUND: OBJECTIVES: METHODS: A left-right comparative study between rapamycin 0·2% topical formulation and vehicle was conducted in 11 patients with TSC. Two formulations, an ointment and a gel, were prepared and in vitro percutaneous absorption of rapamycin was determined. RESULTS: In vitro percutaneous absorption of rapamycin was significantly greater with the gel compared with the ointment. In the clinical study, the rapamycin-treated cheek showed significant improvements relative to the vehicle-treated cheek in all outcome measures after 12 weeks of treatment. The improvement was particularly remarkable in children aged ≤ 10 years. No side-effects were noted, and rapamycin was not detected in the blood of the patients. CONCLUSIONS: Topical rapamycin was significantly effective against angiofibromas. Both formulations used were effective and safe. The 0·2% gel is especially useful because of its better skin penetration and low irritancy. Initiation of topical rapamycin therapy in early childhood would be beneficial for patients with TSC.
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Authors | M Tanaka, M Wataya-Kaneda, A Nakamura, S Matsumoto, I Katayama |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 169
Issue 6
Pg. 1314-8
(Dec 2013)
ISSN: 1365-2133 [Electronic] England |
PMID | 23909960
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 British Association of Dermatologists. |
Chemical References |
- Antibiotics, Antineoplastic
- Gels
- Ointments
- Sirolimus
|
Topics |
- Administration, Cutaneous
- Adolescent
- Adult
- Angiofibroma
(complications, drug therapy)
- Antibiotics, Antineoplastic
(administration & dosage)
- Child
- Child, Preschool
- Facial Neoplasms
(complications, drug therapy)
- Female
- Gels
(administration & dosage)
- Humans
- Male
- Neoplasm Recurrence, Local
(etiology)
- Ointments
(administration & dosage)
- Sirolimus
(administration & dosage)
- Treatment Outcome
- Tuberous Sclerosis
(complications)
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