Abstract | INTRODUCTION: METHODS: Clinical data of 21 transplant patients who underwent LT for FAP between 1996 and 2011 were analyzed retrospectively. RESULTS: The majority of patients had cardiac symptoms (76%), gastrointestinal symptoms (71%), or peripheral polyneuropathy (71%). A conventional operating technique was performed on 11 patients using end-to-end caval anastomoses, while the modified piggyback technique by Belghiti was performed on 10 patients. Overall survival analysis revealed a one-yr survival rate of 74.3% and three- and five-yr survival rates of 60.0% and 52.5%, respectively. Pre-operative modified body mass index (mBMI) <700 kg g/L m² and time interval between diagnosis and operation before LT resulted in significantly lower overall survival (p = 0.0137; p = 0.033). CONCLUSION: The pre-operative nutritional status and time interval between diagnosis and operation before LT influence overall survival after LT for hereditary amyloidosis.
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Authors | Clemens Franz, Katrin Hoffmann, Ulf Hinz, Reinhard Singer, Ernst Hund, Daniel N Gotthardt, Tom Ganten, Arnt Volko Kristen, Ute Hegenbart, Stefan Schönland, Katrin Hinderhofer, Markus W Büchler, Peter Schemmer |
Journal | Clinical transplantation
(Clin Transplant)
2013 Jul-Aug
Vol. 27 Suppl 25
Pg. 40-8
ISSN: 1399-0012 [Electronic] Denmark |
PMID | 23909501
(Publication Type: Clinical Trial, Journal Article)
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Copyright | © 2013 John Wiley & Sons A/S. |
Topics |
- Adult
- Aged
- Amyloidosis, Familial
(diagnosis, mortality, surgery)
- Body Mass Index
- Female
- Follow-Up Studies
- Graft Rejection
(mortality)
- Humans
- Liver Transplantation
(mortality)
- Male
- Middle Aged
- Postoperative Complications
- Prognosis
- Retrospective Studies
- Survival Rate
- Time Factors
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