Antinociceptive effect of Mirabilis jalapa on acute and chronic pain models in mice.
Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: The infusion or decoction of Mirabilis jalapa leaves is used in traditional medicine in Brazil to treat inflammatory and painful diseases. Thus, the present study was designed to investigate whether the leaf ethyl acetate (Eta) fraction from Mirabilis jalapa exhibits antinociceptive effect in clinically relevant pain models in mice. Furthermore, we have investigated the role of cholinergic system in the antinociceptive action produced by Eta in mice. MATERIALS AND METHODS: RESULTS: Eta produced marked reduction in the allodynia caused by CFA, surgical incision and partial sciatic nerve ligation. However, Eta did not alter the paw edema or the increase of IL-1β levels produced by CFA. The antinociceptive effect of Eta was reversed by the pre-treatment of animals with the antagonists of muscarinic ( atropine, 5mg/kg, s.c) or nicotinic ( mecamylamine, 0.001mg/kg, s.c.) receptors. Eta did not alter in vitro acetylcholinesterase activity in blood or spinal cord samples, but it reversed the increase in the acetylcholinesterase activity observed in the spinal cord samples from mice injected with CFA. Moreover, Eta did not alter the indicators of liver or kidney lesion. CONCLUSIONS:
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Authors | Cristiani I B Walker, Gabriela Trevisan, Mateus F Rossato, Cássia R Silva, Franciele V Pinheiro, Carina Franciscato, Etiane Tatsch, Maria B Moretto, Morgana D Silva, Melânia P Manfron, Rafael Noal Moresco, Adair R S Santos, Maria E Pereira, Juliano Ferreira |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 149
Issue 3
Pg. 685-93
(Oct 07 2013)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 23906783
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Analgesics
- Interleukin-1beta
- Plant Extracts
- Acetylcholinesterase
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Topics |
- Acetylcholinesterase
(metabolism)
- Acute Pain
(drug therapy, enzymology, immunology)
- Analgesics
(isolation & purification, therapeutic use, toxicity)
- Animals
- Arthritis, Experimental
(drug therapy, enzymology, immunology)
- Chronic Pain
(drug therapy, enzymology, immunology)
- Hyperalgesia
(drug therapy, enzymology, immunology)
- Interleukin-1beta
(immunology)
- Male
- Mice
- Pain Measurement
- Pain, Postoperative
(drug therapy, enzymology, immunology)
- Plant Extracts
(isolation & purification, therapeutic use, toxicity)
- Plant Leaves
(chemistry)
- Sciatic Neuropathy
(drug therapy, enzymology, immunology)
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