Abstract | AIMS: To assess the association of circulating concentrations of angiopoietin-2 (Ang-2) and its soluble receptor Tie-2 (sTie-2) with all-cause, cardiovascular, and cancer mortality in a population-based sample. METHODS AND RESULTS:
Angiopoietin-2 and sTie-2 were measured in 3220 participants (1665 women; mean age 54.4 years) in the Study of Health in Pomerania (SHIP). Multivariable adjusted hazard ratios (HRs) for mortality were estimated using Cox proportional hazard models. During a median follow-up of 6.2 years, 217 participants died. Ang-2 levels were positively associated with all-cause mortality [HR 1.29; 95% confidence interval (CI) 1.19-1.39 per 1 SD increment; P < 0.001] and cardiovascular mortality (HR 1.32; 95% CI 1.18-1.49; P < 0.001), but not with cancer mortality (HR 1.08; 95% CI 0.89-1.32; P = 0.416). Levels of sTie-2 were not significantly related to all-cause mortality (HR 1.12; 95% CI 0.98-1.27; P = 0.102). Adding Ang-2 to a prediction model for all-cause mortality with standard risk factors slightly improved discrimination (Δ Harrell's C, 0.008; P < 0.001) but not risk reclassification (continuous net reclassification improvement, -0.015; P = 0.571). CONCLUSION: In our community-based sample, higher serum Ang-2 concentrations were associated with greater risk for all-cause and cardiovascular mortality, suggesting that subtle increases in Ang-2 levels might reflect processes such as vascular remodelling that are associated with higher mortality risk. Adding Ang-2 to a mortality prediction model only modestly improved discrimination.
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Authors | Roberto Lorbeer, Sebastian E Baumeister, Marcus Dörr, Matthias Nauck, Anne Grotevendt, Henry Völzke, Ramachandran S Vasan, Henri Wallaschofski, Wolfgang Lieb |
Journal | European journal of heart failure
(Eur J Heart Fail)
Vol. 15
Issue 12
Pg. 1327-34
(Dec 2013)
ISSN: 1879-0844 [Electronic] England |
PMID | 23901057
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiopoietin-2
- Receptor, TIE-2
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Topics |
- Angiopoietin-2
(blood)
- Cardiovascular Diseases
(blood, mortality)
- Female
- Germany
(epidemiology)
- Humans
- Male
- Middle Aged
- Neoplasms
(blood, mortality)
- Population Surveillance
- Proportional Hazards Models
- Receptor, TIE-2
(blood)
- Risk Factors
- Statistics as Topic
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