Abstract | SCOPE: METHODS AND RESULTS: CONCLUSION: Our results provided evidence that curcumin was able to protect SK-N-SH cells against acrolein toxicity. This protection is mediated through the antioxidant, the redox, and the survival regulated pathways by curcumin. Moreover, our results demonstrated that Nps-Cur had higher capacity than curcumin to protect SK-N-SH cells against acrolein.
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Authors | Sihem Doggui, Abdenour Belkacemi, Ghislain Djiokeng Paka, Morgane Perrotte, Rongbiao Pi, Charles Ramassamy |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 57
Issue 9
Pg. 1660-70
(Sep 2013)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 23901044
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Antioxidants
- NF-E2-Related Factor 2
- NF-kappa B
- NFE2L2 protein, human
- Neuroprotective Agents
- Reactive Nitrogen Species
- Reactive Oxygen Species
- Acrolein
- Proto-Oncogene Proteins c-akt
- SIRT1 protein, human
- Sirtuin 1
- Glutamate-Cysteine Ligase
- Glutathione
- Curcumin
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Topics |
- Acrolein
(toxicity)
- Antioxidants
(pharmacology)
- Cell Line, Tumor
- Curcumin
(pharmacology)
- Glutamate-Cysteine Ligase
(genetics, metabolism)
- Glutathione
(metabolism)
- Humans
- NF-E2-Related Factor 2
(genetics, metabolism)
- NF-kappa B
(genetics, metabolism)
- Nanoparticles
(chemistry)
- Neuroblastoma
(metabolism)
- Neurons
(cytology, drug effects)
- Neuroprotective Agents
(pharmacology)
- Oxidation-Reduction
(drug effects)
- Proto-Oncogene Proteins c-akt
(genetics, metabolism)
- Reactive Nitrogen Species
(metabolism)
- Reactive Oxygen Species
(metabolism)
- Signal Transduction
(drug effects)
- Sirtuin 1
(genetics, metabolism)
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