Abstract | OBJECTIVE: METHODS: Four healthy monkeys were injected with diluted MPTP solution continuously through peripheral veins. The behavioral changes of the monkeys were monitored with the Parkinson disease scale for monkeys. 18FDG-PET-CT scans for the whole brain were obtained before and 3 months after the injection of MPTP. The pathological and glucose metabolic changes of the brains were examined. RESULTS: CONCLUSION: The metabolic changes of brains in the monkeys with Parkinson's disease are not limited to the basal ganglion area, which may be an important mechanism for the non-motor symptoms.
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Authors | Peng Li, Zhu-Jun Zhang, Yang Li, Hai-Bo Ren, Shi-Zhen Zhang, Wei Wang |
Journal | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
(Sichuan Da Xue Xue Bao Yi Xue Ban)
Vol. 44
Issue 3
Pg. 362-5
(May 2013)
ISSN: 1672-173X [Print] China |
PMID | 23898513
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fluorodeoxyglucose F18
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- Glucose
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Topics |
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- Animals
- Brain
(metabolism)
- Disease Models, Animal
- Fluorodeoxyglucose F18
- Glucose
(metabolism)
- Haplorhini
- Male
- Parkinson Disease, Secondary
(chemically induced, metabolism)
- Positron-Emission Tomography
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