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[Changes of glucose in the brains of monkeys with MPTP induced Parkinson's disease].

AbstractOBJECTIVE:
To examine the metabolic and behavioral changes of monkeys with MPTP induced Parkinson's disease.
METHODS:
Four healthy monkeys were injected with diluted MPTP solution continuously through peripheral veins. The behavioral changes of the monkeys were monitored with the Parkinson disease scale for monkeys. 18FDG-PET-CT scans for the whole brain were obtained before and 3 months after the injection of MPTP. The pathological and glucose metabolic changes of the brains were examined.
RESULTS:
The animal model of Parkinson's disease was successfully established in all 4 monkeys, showing typical parkinsonian syndromes of bradykinesia, rigidity and hypokinesia. Changes in high nervous activities such as apathetic and less aggressive behaviors were also observed. Their scores of Parkinson disease scale exceeded 20. The parkinsonian syndromes were relieved after the administration of sinemet. The 18FDG-PET-CT scans showed significant glucose reduction after the MPTP injection within and outside of the basal ganglion area.
CONCLUSION:
The metabolic changes of brains in the monkeys with Parkinson's disease are not limited to the basal ganglion area, which may be an important mechanism for the non-motor symptoms.
AuthorsPeng Li, Zhu-Jun Zhang, Yang Li, Hai-Bo Ren, Shi-Zhen Zhang, Wei Wang
JournalSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 44 Issue 3 Pg. 362-5 (May 2013) ISSN: 1672-173X [Print] China
PMID23898513 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fluorodeoxyglucose F18
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Glucose
Topics
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Brain (metabolism)
  • Disease Models, Animal
  • Fluorodeoxyglucose F18
  • Glucose (metabolism)
  • Haplorhini
  • Male
  • Parkinson Disease, Secondary (chemically induced, metabolism)
  • Positron-Emission Tomography

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