c-MET and HGF mRNA expression in hepatocellular carcinoma: correlation with clinicopathological features and survival.

Abstract

BACKGROUND/AIM:

Data on the clinicopathological features and prognostic impact of c-N-Methyl-N'-nitro-N-nitroso-guanidine HOS Transforming gene (c-MET) and hepatocyte growth factor (HGF) in hepatocellular carcinoma (HCC) are inconsistent. We assessed c-MET and HGF expression in 49 patients with early-stage HCC and correlated the results with disease characteristics and survival.

MATERIALS AND METHODS:

Expression of c-MET and HGF mRNA in tumor (T) and non-tumor (NT) tissues was assessed. Results were correlated with patient characteristics and overall and recurrence-free survival.

RESULTS:

Median relative tumor c-MET and HGF expressions were 3.23 (T/NT ratio 6.46) and 9.07 (T/NT ratio 0.77), respectively. c-MET and HGF were overexpressed in early-stage disease with favorable characteristics although there was no association with survival.

CONCLUSION:

Contrary to other studies, in our series increased tumor c-MET and HGF expressions were associated with favorable disease attributes but not with survival. The prognostic and therapeutic applications of this knowledge to HCC are under active investigation.

• Authors: Celina Su-Ping Ang, Mark Yipin Sun, David Fidel Huitzil-Melendez, Joanne Fu-Lou Chou, Marinela Capanu, William Jarnagin, Yuman Fong, Ronald Paul Dematteo, Michael D'Angelica, Peter Allen, Chin-Tung Chen, Eileen Mary O'Reilly, Martin Ross Weiser, Ghassan Khaled Abou-Alfa
• Journal: Anticancer research (Anticancer Res) Vol. 33 Issue 8 Pg. 3241-5 (Aug 2013) ISSN: 1791-7530 [Electronic] Greece
• PMID: 23898085 (Publication Type: Journal Article)

Chemical References

• HGF protein, human
• RNA, Messenger
• Hepatocyte Growth Factor
• Proto-Oncogene Proteins c-met

Topics

• Aged
• Aged, 80 and over
• Carcinoma, Hepatocellular (genetics, pathology)
• Demography
• Female
• Gene Expression Regulation, Neoplastic
• Hepatocyte Growth Factor (genetics, metabolism)
• Humans
• Liver Neoplasms (genetics, pathology)
• Male
• Middle Aged
• Proto-Oncogene Proteins c-met (genetics, metabolism)
• RNA, Messenger (genetics, metabolism)
• Survival Analysis