Predictors of methamphetamine psychosis: history of ADHD-relevant childhood behaviors and drug exposure.

Abstract

The goal of this study was to extend our previous research that reported a significant association between Attention Deficit Hyperactivity Disorder (ADHD)-relevant childhood behaviors and the frequency of methamphetamine (MA)-induced psychotic symptoms in an expanded sample. 190 participants who met DSM-IV criteria for MA dependence were administered the Methamphetamine Experience Questionnaire that assessed MA-induced psychosis. Data related to MA exposure, comorbid drug use, education, familial psychiatric history and assessments of ADHD-relevant childhood behaviors as measured by the Wender Utah Rating Scale (WURS) were collected. Although WURS scores did not differ between 145 MAP+ and 45 MAP- subjects, MAP+ subjects with higher WURS scores were significantly more likely to report more frequent psychosis. Although mean daily MA dosage did not differ between the MAP+ and MAP- subjects, MAP+ subjects who consumed larger doses of MA were significantly more likely to experience frequent psychosis. These data suggest that ADHD-relevant childhood behaviors may interact with MA exposure to reflect a neurobiological vulnerability related to the emergence of frequent MA-induced psychotic symptoms. These results may elucidate factors that contribute to the psychiatric sequelae of MA abuse.

• Authors: Ruth Salo, Catherine Fassbender, Ana-Maria Iosif, Stefan Ursu, Martin H Leamon, Cameron Carter
• Journal: Psychiatry research (Psychiatry Res) Vol. 210 Issue 2 Pg. 529-35 (Dec 15 2013) ISSN: 1872-7123 [Electronic] Ireland
• PMID: 23896355 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Central Nervous System Stimulants
• Methamphetamine

Topics

• Adult
• Amphetamine-Related Disorders (psychology)
• Attention Deficit Disorder with Hyperactivity (diagnosis, psychology)
• Central Nervous System Stimulants (adverse effects)
• Comorbidity
• Diagnostic and Statistical Manual of Mental Disorders
• Female
• Humans
• Interviews as Topic
• Male
• Methamphetamine (adverse effects)
• Middle Aged
• Predictive Value of Tests
• Psychoses, Substance-Induced (diagnosis, epidemiology, psychology)
• Surveys and Questionnaires