Abstract | BACKGROUND: Frequent sessions of endoscopic dilatation are usually required in the management of benign esophageal strictures, especially caustic induced ones. Topical mitomycin C (MMC) has been recently used in the management of resistant strictures. This study evaluated the efficacy of MMC application in prevention of stricture recurrence after endoscopic dilatation. PATIENTS AND METHODS: This double-blind, randomized, placebo-controlled trial included forty patients with caustic esophageal strictures dating from January 2008 to October 2010. Patients were randomized into 2 groups to undergo endoscopic dilatation with application of either MMC versus placebo on stricture site. Regular follow up and re-evaluation were done after 6 months of management. The number of dilatation sessions needed for resolution of dysphagia in each group was our primary outcome. RESULTS: During the specified follow up period, 80 % of strictures in the MMC group got completely resolved compared to only 35% in the placebo group. The mean number of dilatation sessions needed in the MMC group was n = 3.85 ± 2.08 compared to n = 6.9 ± 2.12 in the placebo group which was statistically significant (p < 0.001). CONCLUSION:
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Authors | Khaled M El-Asmar, Mohamed A Hassan, Hesham M Abdelkader, Alaa F Hamza |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 48
Issue 7
Pg. 1621-7
(Jul 2013)
ISSN: 1531-5037 [Electronic] United States |
PMID | 23895984
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Administration, Topical
- Burns, Chemical
(drug therapy)
- Caustics
(toxicity)
- Child, Preschool
- Double-Blind Method
- Esophageal Stenosis
(chemically induced, drug therapy)
- Female
- Humans
- Male
- Mitomycin
(administration & dosage)
- Prospective Studies
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