[Comparative evaluation of the antiviral efficacy of virazole and ribamidil in experimental Lassa fever in monkeys].

Abstract

Lassa virus administered to monkeys aerogenically induced in these laboratory animals a fatal disease modelling the severe course of human Lassa fever. It was demonstrated experimentally that ribamydil, a Soviet analogue of virasol, as well as foreign commercial virasol was therapeutically effective in experimental Lassa fever in aerogenically infected monkeys.

• Authors: V I Dvoretskaia, A A Evseev, G V Bogatikov, V A Pshenichnov
• Journal: Voprosy virusologii (Vopr Virusol) 1990 Mar-Apr Vol. 35 Issue 2 Pg. 151-2 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'naia otsenka protivovirusnoĭ éffektivnosti virazola i ribamidila pri éksperimental'noĭ likhoradke Lassa u obez'ian.
• PMID: 2389569 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Ribonucleosides
• Ribavirin

Topics

• Animals
• Drug Evaluation, Preclinical
• Injections, Intramuscular
• Lassa Fever (drug therapy, mortality)
• Papio
• Ribavirin (therapeutic use)
• Ribonucleosides (therapeutic use)