Abstract | INTRODUCTION: Differing patterns of neurophysiological abnormalities have been reported in patients with Fisher syndrome. Fisher syndrome is rare, and few series have incorporated prospective serial studies to define the natural history of nerve conduction studies in Guillain-Barré syndrome. METHODS: RESULTS: Of the 36 Guillain-Barré syndrome patients identified within 2 years, 17 had features of Fisher syndrome. Serial nerve conduction studies detected significant abnormalities in sensory nerve action potential amplitude in 94% of patients associated with 2 patterns of recovery-non-demyelinating reversible distal conduction failure and axonal regeneration. Similar changes were seen in motor nerves of 5 patients. CONCLUSIONS: Patients with the Fisher syndrome spectrum of illness have significant sensory involvement, which may only be evident with serial neurophysiological studies.
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Authors | Nortina Shahrizaila, Khean J Goh, Norito Kokubun, Ai H Tan, Cheng Y Tan, Nobuhiro Yuki |
Journal | Muscle & nerve
(Muscle Nerve)
Vol. 49
Issue 4
Pg. 558-63
(Apr 2014)
ISSN: 1097-4598 [Electronic] United States |
PMID | 23893512
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Wiley Periodicals, Inc. |
Topics |
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- Male
- Middle Aged
- Miller Fisher Syndrome
(diagnosis, physiopathology)
- Neural Conduction
(physiology)
- Prospective Studies
- Sensory Receptor Cells
(pathology, physiology)
- Young Adult
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