Staphylococcus aureus bacteremia in an Indian tertiary care hospital: observational study on clinical epidemiology, resistance characteristics, and carriage of the Panton-Valentine leukocidin gene.

Abstract

OBJECTIVES:

To analyze the epidemiology and laboratory characteristics of Staphylococcus aureus bacteremia (SAB) in an Indian tertiary care hospital.

METHODS:

We collected clinical, epidemiological, and laboratory data of all cases of SAB during August 2010 through July 2011. All isolates were tested for the Panton-Valentine leukocidin (PVL) gene.

RESULTS:

Eighteen percent of all blood stream infections (BSIs) were attributable to S. aureus. Among a total of 70 cases of SAB, 54% were due to methicillin-resistant S. aureus (MRSA) and 46% to methicillin-susceptible S. aureus (MSSA). Seventy-four percent of the cases had community-acquired (CA) SAB, among whom 69% had been hospitalized previously. Skin and soft tissue infections (SSTI) (30%) and respiratory infections (24%) were the common sources of bacteremia. The overall case fatality rate was 27%, and a similar percentage (23%) of patients discontinued therapy due to a poor medical outcome. The PVL gene was detected in 16% of S. aureus isolates, predominantly in CA-S. aureus (82%). SSTIs and pneumonia were the common sources of bacteremia in 45% of patients infected with a PVL-positive strain.

CONCLUSIONS:

S. aureus is a significant cause of BSI with a case fatality rate comparable to those of other developing nations. The upsurge in MRSA rates is alarming in our setup. Antibiotic stewardship and strict control of antibiotic use must be implemented by health care professionals to curb the increasing trend in MRSA BSIs.

• Authors: Vandana Kalwaje Eshwara, Frenil Munim, Chaitanya Tellapragada, Asha Kamath, Muralidhar Varma, Leslie Edward Lewis, Chiranjay Mukhopadhyay
• Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (Int J Infect Dis) Vol. 17 Issue 11 Pg. e1051-5 (Nov 2013) ISSN: 1878-3511 [Electronic] Canada
• PMID: 23891294 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Bacterial Toxins
• Exotoxins
• Leukocidins
• Panton-Valentine leukocidin

Topics

• Adolescent
• Adult
• Aged
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Bacteremia (drug therapy, epidemiology, microbiology)
• Bacterial Toxins (genetics)
• Child
• Child, Preschool
• Cross Infection (drug therapy, epidemiology, microbiology)
• Drug Resistance, Neoplasm
• Exotoxins (genetics)
• Female
• Humans
• India (epidemiology)
• Infant
• Infant, Newborn
• Leukocidins (genetics)
• Male
• Microbial Sensitivity Tests
• Middle Aged
• Prevalence
• Prospective Studies
• Staphylococcal Infections (drug therapy, epidemiology, microbiology)
• Staphylococcus aureus (genetics)
• Tertiary Care Centers
• Treatment Outcome
• Young Adult