Abstract | BACKGROUND: Ectonucleotidase plays an important role in the regulation of cardiac function by controlling extracellular levels of adenine nucleotides and adenosine. To determine the influence of ischemia-reperfusion injury on ectonucleotidase activity in coronary vascular bed, we compared the metabolic profile of adenine nucleotides during the coronary circulation in pre- and post-ischemic heart. METHODS: RESULTS: CONCLUSION: Ectonucleotidases were liberated from the coronary vascular bed by ischemia-reperfusion, resulting in an overall decrease in ectonucleotidase activity in the post-ischemic coronary vascular bed. These results suggest that decreased ectonucleotidase activity by ischemia may exacerbate subsequent reperfusion injury, and that levels of circulating ectonucleotidase may reflect the severity of ischemic vascular injury.
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Authors | Kaoru Takahashi-Sato, Masahiro Murakawa, Junko Kimura, Masa-aki Ito, Isao Matsuoka |
Journal | BMC cardiovascular disorders
(BMC Cardiovasc Disord)
Vol. 13
Pg. 53
(Jul 28 2013)
ISSN: 1471-2261 [Electronic] England |
PMID | 23890190
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adenine Nucleotides
- Antigens, CD
- Nucleotidases
- adenosine monophosphatase
- 5'-Nucleotidase
- Phosphoric Diester Hydrolases
- ectonucleotide pyrophosphatase phosphodiesterase 1
- Adenosine Triphosphatases
- Pyrophosphatases
- Apyrase
- CD39 antigen
- Adenosine
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Topics |
- 5'-Nucleotidase
(blood)
- Adenine Nucleotides
(administration & dosage, blood)
- Adenosine
(administration & dosage, blood)
- Adenosine Triphosphatases
(blood)
- Aging
(blood)
- Animals
- Antigens, CD
(blood)
- Apyrase
(blood)
- Coronary Vessels
(enzymology)
- Endothelium, Vascular
(enzymology)
- Heart Rate
(drug effects)
- In Vitro Techniques
- Male
- Nucleotidases
(blood)
- Phosphoric Diester Hydrolases
(blood)
- Pyrophosphatases
(blood)
- Rats, Wistar
- Reperfusion Injury
(enzymology, physiopathology)
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