[Nootropics and antioxidants in the complex therapy of symptomatic posttraumatic epilepsy].

Abstract

To study the possibility of application of nootropics and antioxidants in the complex antiepileptic therapy, we examined 75 patients with symptomatic focal posttraumatic epilepsy. A statistically significant reduction in the number of epileptic seizures, improvement of cognitive function and quality of life of the patients as well as a decrease in the severity of depression and epileptic changes in the EEG were identified. The potentiation of antiepileptic activity of basic drugs, normalization of brain's electrical activity and reduction in EEG epileptiform activity, in particular coherent indicators of slow-wave activity, were noted after treatment with the antioxidant mexidol. A trend towards the improvement of neuropsychological performance and quality of life was observed. There was a lack of seizure aggravation typical of many nootropic drugs. Thus, phenotropil and mexidol can be recommended for complex treatment of symptomatic posttraumatic epilepsy.

• Authors: A A Savenkov, O L Badalian, G N Avakian
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 113 Issue 6 Pg. 26-34 ( 2013) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 23887448 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antioxidants
• Nootropic Agents
• Picolines
• emoxypine succinate
• 4-phenylpiracetam
• Piracetam

Topics

• Adolescent
• Adult
• Antioxidants (therapeutic use)
• Cognition (drug effects, physiology)
• Drug Therapy, Combination
• Electroencephalography (drug effects)
• Epilepsy, Post-Traumatic (diagnosis, drug therapy, physiopathology)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Nootropic Agents (therapeutic use)
• Picolines (therapeutic use)
• Piracetam (analogs & derivatives, therapeutic use)
• Treatment Outcome
• Young Adult