A patient with nephrotic-range proteinuria and focal global glomerulosclerosis.

Abstract

A young male is evaluated for nephrotic-range proteinuria, hypercalciuria, and an elevated serum creatinine. A renal biopsy is performed and shows focal global glomerulosclerosis. The absence of nephrotic syndrome suggest that glomerulosclerosis was a secondary process. Further analysis of the proteinuria showed it to be due mainly to low-molecular weight proteins. The case illustrates the crucial role of electron microscopy as well as evaluation of the identity of the proteinuria that accompanies a biopsy finding of focal and global or focal and segmental glomerulosclerosis.

• Authors: Fernando C Fervenza
• Journal: Clinical journal of the American Society of Nephrology : CJASN (Clin J Am Soc Nephrol) Vol. 8 Issue 11 Pg. 1979-87 (Nov 2013) ISSN: 1555-905X [Electronic] United States
• PMID: 23886564 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• CLC-5 chloride channel
• Chloride Channels
• Sodium Chloride Symporter Inhibitors
• Creatinine

Topics

• Adolescent
• Biomarkers (blood)
• Biopsy
• Chloride Channels (genetics)
• Creatinine (blood)
• Dent Disease (blood, complications, diagnosis, drug therapy, genetics)
• Frameshift Mutation
• Genetic Predisposition to Disease
• Glomerulosclerosis, Focal Segmental (blood, diagnosis, drug therapy, etiology)
• Humans
• Hypercalciuria (etiology)
• Male
• Nephrosis (blood, diagnosis, drug therapy, etiology)
• Phenotype
• Predictive Value of Tests
• Proteinuria (blood, diagnosis, drug therapy, etiology)
• Sodium Chloride Symporter Inhibitors (therapeutic use)
• Treatment Outcome