Adrenal adenoma with excess secretion of corticosterone and 18-hydroxycorticosterone.

Abstract

A 64-year-old man with sudden onset of quadriplegia due to marked hypokalemia was referred to our clinic with suppressed plasma renin activity in the presence of a low aldosterone level. Computerized tomography demonstrated a left adrenal adenoma, shown on adrenal scintigraphy to be functioning. The elevated basal level of plasma corticosterone and its increased response to 1-24 adrenocorticotropic hormone suggested the tumor produced corticosterone. The surgical specimen was a benign adrenocortical adenoma with excess content of corticosterone and 18-hydroxycorticosterone.

• Authors: M Morioka, Y Sen, K Inoue, Y Fujita
• Journal: The Journal of urology (J Urol) Vol. 144 Issue 3 Pg. 731-2 (Sep 1990) ISSN: 0022-5347 [Print] United States
• PMID: 2388339 (Publication Type: Case Reports, Journal Article)

Chemical References

• 18-Hydroxycorticosterone
• Corticosterone

Topics

• 18-Hydroxycorticosterone (metabolism)
• Adenoma (metabolism)
• Adrenal Cortex Neoplasms (metabolism)
• Corticosterone (analogs & derivatives, metabolism)
• Humans
• Hypokalemia (etiology)
• Male
• Middle Aged
• Quadriplegia (etiology)