Imidafenacin, an antimuscarinic agent, improves nocturia and reduces nocturnal urine volume.

Abstract

OBJECTIVE:

To evaluate the efficacy of imidafenacin for nocturia and nocturnal polyuria in patients with overactive bladder.

MATERIALS AND METHODS:

A stratified analysis was conducted on data from a phase III randomized, double-blind, controlled trial of imidafenacin performed at 158 centers in Japan. The subjects received imidafenacin (0.1 mg) twice daily (group I) or placebo twice daily (group P). The 24-hour urine volume, daytime and nighttime voiding frequency, and volume voided/micturition were evaluated from 3-day voiding diaries recorded every 4 weeks during the 12-week study period. Longitudinal data analysis was performed, with all values expressed as the least squares mean ± standard error.

RESULTS:

A total of 46 patients (mean age 66.54 ± 9.38 years, 9 men and 37 women) with nocturia and nocturnal polyuria (>33% of urine production at night) were enrolled. Group I (n = 35) and group P (n = 11) showed no baseline differences in the daily voided volume, concomitant diseases, age, or body weight. However, the average daily number of micturitions differed (11.22 ± 2.17 vs 14.45 ± 2.85). Therefore, longitudinal data analysis was performed for each micturition pattern. After 12 weeks of treatment, nighttime micturition was significantly less frequent in group I than in group P (P = .0292), and the nocturnal percentage of 24-hour production was significantly smaller (P = .0053). The interval to the first nighttime void was significantly longer in group I than in group P, but no difference was found in the first nighttime voided volume.

CONCLUSION:

The novel antimuscarinic agent, imidafenacin, decreases the number of urinations and reduces nocturnal urine production, thereby improving both nocturia and nocturnal polyuria.

• Authors: Osamu Yokoyama, Yukio Homma, Osamu Yamaguchi
• Journal: Urology (Urology) Vol. 82 Issue 3 Pg. 515-20 (Sep 2013) ISSN: 1527-9995 [Electronic] United States
• PMID: 23876590 (Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved.

Chemical References

• Imidazoles
• Muscarinic Antagonists
• imidafenacin

Topics

• Aged
• Double-Blind Method
• Female
• Humans
• Imidazoles (pharmacology, therapeutic use)
• Male
• Middle Aged
• Muscarinic Antagonists (pharmacology, therapeutic use)
• Nocturia (drug therapy)
• Polyuria (drug therapy)
• Time Factors
• Urination (drug effects)
• Urine