Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases.

Abstract

Resveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and health-related use.

• Authors: Albino Carrizzo, Maurizio Forte, Antonio Damato, Valentina Trimarco, Francesco Salzano, Michelangelo Bartolo, Anna Maciag, Annibale A Puca, Carmine Vecchione
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 61 Pg. 215-26 (Nov 2013) ISSN: 1873-6351 [Electronic] England
• PMID: 23872128 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Antioxidants
• Stilbenes
• Resveratrol

Topics

• Antioxidants (pharmacology)
• Biological Availability
• Cardiovascular Diseases (drug therapy, metabolism)
• Cerebrovascular Disorders (drug therapy, metabolism)
• Clinical Trials as Topic
• Diabetes Mellitus (drug therapy, metabolism)
• Humans
• Metabolic Diseases (drug therapy, metabolism)
• Oxidation-Reduction
• Oxidative Stress (drug effects)
• Resveratrol
• Stilbenes (pharmacokinetics, pharmacology)