Abstract |
Immunosuppressive regimens that effectively prevent graft-versus-host disease (GVHD) after allogeneic blood or marrow transplantation (allo-BMT) have been associated with an increased incidence of post- transplantation lymphoproliferative disorder (PTLD) in the first year after transplantation. We evaluated the incidence of PTLD associated with the use of high-dose post- transplantation cyclophosphamide (PTCy) as GVHD prophylaxis. Between 2000 and 2011, a total of 785 adult allo-BMT recipients were given PTCy as GVHD prophylaxis at the Johns Hopkins Hospital, including 313 patients who received PTCy as sole GVHD prophylaxis. HLA-haploidentical or unrelated donor graft transplantation was performed in 526 patients (67%). No cases of PTLD occurred during the first year after allo-BMT in this series. PTLD is a rare occurrence after allo-BMT using PTCy, even in high-risk alternative donor transplantations.
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Authors | Jennifer A Kanakry, Yvette L Kasamon, Javier Bolaños-Meade, Ivan M Borrello, Robert A Brodsky, Ephraim J Fuchs, Nilanjan Ghosh, Douglas E Gladstone, Christopher D Gocke, Carol Ann Huff, Christopher G Kanakry, Leo Luznik, William Matsui, Huzefa J Mogri, Lode J Swinnen, Heather J Symons, Richard J Jones, Richard F Ambinder |
Journal | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
(Biol Blood Marrow Transplant)
Vol. 19
Issue 10
Pg. 1514-7
(Oct 2013)
ISSN: 1523-6536 [Electronic] United States |
PMID | 23871780
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2013 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antineoplastic Agents, Alkylating
- Immunosuppressive Agents
- Cyclophosphamide
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Topics |
- Adolescent
- Adult
- Aged
- Antineoplastic Agents, Alkylating
(therapeutic use)
- Bone Marrow Transplantation
(methods)
- Cyclophosphamide
(therapeutic use)
- Female
- Graft vs Host Disease
(drug therapy, prevention & control)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Lymphoma
(drug therapy, surgery, therapy)
- Male
- Middle Aged
- Transplantation, Homologous
(methods)
- Young Adult
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