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The association of the 174G>C polymorphism of interleukin 6 gene with diabetic nephropathy in patients with type 2 diabetes mellitus.

AbstractAIMS:
To evaluate the association of 174G>C polymorphism on interleukin-6 (IL-6) gene with diabetic nephropathy in patients with type 2 diabetes.
METHODS:
A total of 393 Greek subjects with type 2 diabetes (mean age 66.5±10.0years, men n=203, women n=190) were examined. Diabetic nephropathy was defined as presence of microalbuminuria and/or proteinuria. The IL-6 174G>C polymorphism was detected by polymerase chain reaction and appropriate restriction enzyme digestion. High sensitivity C-reactive protein was assayed by particle-enhanced immunonephelometry.
RESULTS:
The genotype distribution (%) was GG: 49.1, GC: 26.8 and CC: 24.1, with no gender difference. The CC homozygotes had lower albumin excretion (mg/24h) in comparison with the GC genotype [CC: 8.9 (4.0-20.9) vs GC: 21.95 (9.1-53.35), P=0.004]. Participants with the GC genotype tended to have more frequently nephropathy than those with the GG or the CC genotype [GC: 44.55% vs GG: 35.1% and CC: 28.3%, P=0.07)]. The CC homozygotes in comparison with GC heterozygotes had lower odds to have nephropathy (odds ratio: 0.51, 95% confidence intervals=0.28-0.91, P=0.02), even after adjustment for sex, age, duration of diabetes, body mass index, smoking, hypertension, lipids and glycated hemoglobin, (P=0.01).
CONCLUSION:
In type 2 diabetes states, CC homozygotes have lower albumin excretion and are protected from nephropathy in comparison with GC genotypes.
AuthorsStavroula Papaoikonomou, Nicholas Tentolouris, Dimitris Tousoulis, Dimitris Papadodiannis, Antigoni Miliou, Nikolaos Papageorgiou, George Hatzis, Christodoulos Stefanadis
JournalJournal of diabetes and its complications (J Diabetes Complications) 2013 Nov-Dec Vol. 27 Issue 6 Pg. 576-9 ISSN: 1873-460X [Electronic] United States
PMID23871133 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2013.
Chemical References
  • IL6 protein, human
  • Interleukin-6
Topics
  • Aged
  • Diabetes Mellitus, Type 2 (complications, epidemiology, genetics)
  • Diabetic Nephropathies (epidemiology, genetics)
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Interleukin-6 (genetics)
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide

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