Abstract | AIMS: METHODS: RESULTS: The genotype distribution (%) was GG: 49.1, GC: 26.8 and CC: 24.1, with no gender difference. The CC homozygotes had lower albumin excretion (mg/24h) in comparison with the GC genotype [CC: 8.9 (4.0-20.9) vs GC: 21.95 (9.1-53.35), P=0.004]. Participants with the GC genotype tended to have more frequently nephropathy than those with the GG or the CC genotype [GC: 44.55% vs GG: 35.1% and CC: 28.3%, P=0.07)]. The CC homozygotes in comparison with GC heterozygotes had lower odds to have nephropathy (odds ratio: 0.51, 95% confidence intervals=0.28-0.91, P=0.02), even after adjustment for sex, age, duration of diabetes, body mass index, smoking, hypertension, lipids and glycated hemoglobin, (P=0.01). CONCLUSION: In type 2 diabetes states, CC homozygotes have lower albumin excretion and are protected from nephropathy in comparison with GC genotypes.
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Authors | Stavroula Papaoikonomou, Nicholas Tentolouris, Dimitris Tousoulis, Dimitris Papadodiannis, Antigoni Miliou, Nikolaos Papageorgiou, George Hatzis, Christodoulos Stefanadis |
Journal | Journal of diabetes and its complications
(J Diabetes Complications)
2013 Nov-Dec
Vol. 27
Issue 6
Pg. 576-9
ISSN: 1873-460X [Electronic] United States |
PMID | 23871133
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013. |
Chemical References |
- IL6 protein, human
- Interleukin-6
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Topics |
- Aged
- Diabetes Mellitus, Type 2
(complications, epidemiology, genetics)
- Diabetic Nephropathies
(epidemiology, genetics)
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- Humans
- Interleukin-6
(genetics)
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
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