Anti-ganglioside antibodies in patients with Guillain Barré syndrome and other neurological disorders.

Abstract

A study was performed on 59 Guillain-Barré syndrome (GBS) cases, 58 neurological controls (NC) and 60 non-neurological controls (NNC) to investigate the association of anti-ganglioside antibodies in GBS and other neurological disorders. Campylobacter jejuni was isolated from 5.7% of GBS patients. Anti-ganglioside immunoglobulin G was present in 82% and immunoglobulin M in 46% in acute inflammatory demyelinating polyneuropathy patients, 70% and 44% respectively in acute motor axonal neuropathy subgroup and 38% each in acute motor sensory axonal neuropathy subgroup. Though high intensity of anti-gangliosides was present in the GBS patients, the NC patients also had adequate anti-gangliosides compared with the NNC group.

• Authors: C Vaishnavi, C Behura, S Prabhakar, A Sharma, P Kharbanda
• Journal: Indian journal of medical microbiology (Indian J Med Microbiol) 2013 Apr-Jun Vol. 31 Issue 2 Pg. 177-9 ISSN: 1998-3646 [Electronic] United States
• PMID: 23867676 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Gangliosides
• Immunoglobulin G
• Immunoglobulin M

Topics

• Autoantibodies (blood)
• Campylobacter jejuni (isolation & purification)
• Gangliosides (immunology)
• Guillain-Barre Syndrome (immunology, pathology)
• Humans
• Immunoglobulin G (blood)
• Immunoglobulin M (blood)
• Nervous System Diseases (immunology, pathology)