[Possibility of memory reparation: conditioned freezing disrupted by protein synthesis inhibition can be restored by reminder stimulation in mice].

Abstract

Memory consolidation is a term used to describe the process of memory stabilization from labile, easily disrupted state into disruption-resistant long-term form. Protein synthesis inhibitors injected before or immediately after learning episode, produce significant amnesia. However in a limited number of studies the possibility of memory recovery after such pharmacologically-produced amnesia was shown. The aim of present study was to investigate the possibility of memory recovery in single-session fear conditioning paradigm in mice. Mice were injected with protein synthesis inhibitor cycloheximide twenty minutes prior learning to induce amnesia. Twenty four hours after training mice were subjected to reminder shock, similar to one used during training. Amnestic animals have demonstrated complete recovery of cued fear memory to the level of normal animals when tested 24h after reminder presentation. Thus our data indicate that specific type of memory might be restored using nonspecific stimulus as a reminder. Possible mechanisms of memory reparation after PSI injection during learning are discussed.

• Authors: E M Amel'chenko, S V Zvorykina, D V Bezriadnov, S A Chekhov, K V Anokhin
• Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova (Zh Vyssh Nerv Deiat Im I P Pavlova) 2013 Mar-Apr Vol. 63 Issue 2 Pg. 227-34 ISSN: 0044-4677 [Print] Russia (Federation)
• PMID: 23866609 (Publication Type: Journal Article)

Chemical References

• Protein Synthesis Inhibitors
• Cycloheximide

Topics

• Amnesia (chemically induced, physiopathology)
• Animals
• Conditioning, Psychological
• Cycloheximide (pharmacology, toxicity)
• Fear (physiology)
• Humans
• Learning (drug effects, physiology)
• Memory (drug effects, physiology)
• Mice
• Protein Synthesis Inhibitors (pharmacology, toxicity)
• Time Factors