Abstract | BACKGROUND/AIMS: METHODS: Adult male Sprague-Dawley rats were allocated into five groups: control, PQ (35 mg/kg, intraperitoneal injection), and PQ + CP (1.5, 15, or 30 mg/kg). The dimensions of lung lesions were determined using X-ray microtomography (micro-CT), and histological changes and cytokine levels were recorded. RESULTS: CONCLUSIONS: A CP dose of > 15 mg/kg is effective for reducing the severity of PQ-induced lung injury as determined by histological and micro-CT tissue examination, possibly by modulating antioxidant enzyme and TGF-β1 levels.
|
Authors | Jae-Sung Choi, Sung-Shick Jou, Mee-Hye Oh, Young-Hee Kim, Min-Ju Park, Hyo-Wook Gil, Ho-Yeon Song, Sae-Yong Hong |
Journal | The Korean journal of internal medicine
(Korean J Intern Med)
Vol. 28
Issue 4
Pg. 420-7
(Jul 2013)
ISSN: 2005-6648 [Electronic] Korea (South) |
PMID | 23864800
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Cytokines
- Immunosuppressive Agents
- Inflammation Mediators
- Tgfb1 protein, rat
- Transforming Growth Factor beta1
- Cyclophosphamide
- Catalase
- Superoxide Dismutase
- Paraquat
|
Topics |
- Acute Lung Injury
- Animals
- Catalase
(metabolism)
- Cyclophosphamide
(pharmacology)
- Cytokines
(metabolism)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Immunosuppressive Agents
(pharmacology)
- Inflammation Mediators
(metabolism)
- Lung
(diagnostic imaging, drug effects, metabolism, pathology)
- Lung Injury
(chemically induced, diagnosis, drug therapy, metabolism)
- Male
- Oxidative Stress
(drug effects)
- Paraquat
- Pulmonary Edema
(chemically induced, diagnosis, drug therapy, metabolism)
- Rats
- Rats, Sprague-Dawley
- Severity of Illness Index
- Superoxide Dismutase
(metabolism)
- Transforming Growth Factor beta1
(metabolism)
- X-Ray Microtomography
|