[A case of metastatic colon cancer effectively treated by XELOX and IRIS].

Abstract

The patient was a 78-year-old woman who suffered from right upper quadrant pain. She was diagnosed as colon cancer with hepatic metastasis. Initial chemotherapy using capecitabine plus oxaliplatin(XELOX)+bevacizumab achieved partial response. After 12 months, XELOX was discontinued due to Grade 3 hand-foot syndrome and peripheral neuropathy. Irinotecan plus oral S-1(a combination of tegafur, 5-chloro-2, 4-dihydroxypyridine, and potassium oxonate)and(IRIS)+bevacizumab were continued as second-line therapy, and her status was maintained as stable disease. XELOX and IRIS regimens do not require catheter placement and long infusion process, providing a great advantage to patients.

• Authors: Toshihiro Nishizawa, Satoshi Kinoshita, Takashi Sakuno, Yoichi Fujiyama, Miho Kikuchi, Hiroshi Kaneko, Hidekazu Suzuki, Masahiko Takahashi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 6 Pg. 807-9 (Jun 2013) ISSN: 0385-0684 [Print] Japan
• PMID: 23863664 (Publication Type: Case Reports, Journal Article)

Chemical References

• Drug Combinations
• Oxaloacetates
• Deoxycytidine
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Capecitabine
• Irinotecan
• Fluorouracil
• Camptothecin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives)
• Capecitabine
• Colonic Neoplasms (drug therapy, pathology)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Drug Combinations
• Female
• Fluorouracil (administration & dosage, analogs & derivatives)
• Humans
• Irinotecan
• Liver Neoplasms (drug therapy, secondary)
• Oxaloacetates
• Oxonic Acid (administration & dosage)
• Tegafur (administration & dosage)
• Tomography, X-Ray Computed