[A case of gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor].

Abstract

We report a case of gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor (G-CSF). A 60- year-old man was admitted to our hospital complaining of upper abdominal pain. Endoscopic examination revealed a large type 5 advanced gastric cancer with bleeding from the low body of stomach to the antrum, accompanied with para-aortic and mesenteric lymph node metastasis. He had marked leukocytosis, and serum levels of G-CSF were elevated. Histological diagnosis of the biopsy specimen was adenosquamous carcinoma producing G-CSF. We attempted combination chemotherapy with docetaxel, cisplatin and S-1(DCS). After 1 course of treatment, the primary lesion was reduced in size. However, the size of the metastatic lymph node was larger. Chemotherapy was not effective enough, and the patient died 3 months after ending chemotherapy.

• Authors: Hiroto Saito, Katsunobu Oyama, Sachio Fushida, Tomoya Tsukada, Kouichi Okamoto, Nobukazu Nakanuma, Jun Kinoshita, Isamu Makino, Keishi Nakamura, Hironori Hayashi, Masafumi Inokuchi, Hisatoshi Nakagawara, Tomoharu Miyashita, Hideto Fujita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Hirohisa Kitagawa, Takashi Fujimura, Tetsuo Ohta
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 6 Pg. 799-802 (Jun 2013) ISSN: 0385-0684 [Print] Japan
• PMID: 23863662 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Biomarkers, Tumor
• Drug Combinations
• Taxoids
• Granulocyte Colony-Stimulating Factor
• S 1 (combination)
• Tegafur
• Docetaxel
• Oxonic Acid
• Cisplatin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor (biosynthesis, blood)
• Biopsy
• Carcinoma, Adenosquamous (chemistry, drug therapy, metabolism, pathology)
• Cisplatin (therapeutic use)
• Docetaxel
• Drug Combinations
• Fatal Outcome
• Granulocyte Colony-Stimulating Factor (blood, chemistry)
• Humans
• Male
• Oxonic Acid (therapeutic use)
• Stomach Neoplasms (chemistry, drug therapy, metabolism, pathology)
• Taxoids (therapeutic use)
• Tegafur (therapeutic use)
• Tomography, X-Ray Computed