HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of bronchodilators on regional lung sound distribution in patients with chronic obstructive pulmonary disease.

AbstractBACKGROUND:
Bronchodilators have been reported to influence regional lung ventilation in patients with chronic obstructive pulmonary disease (COPD), which may change regional lung sound distribution. Vibration response imaging (VRI) is a lung imaging system for the assessment of breath sounds.
OBJECTIVE:
To evaluate the effects of a short-acting β2-agonist (SABA) on the regional distribution of lung sounds in COPD patients.
METHODS:
A double-blind crossover trial was performed to compare the treatment of COPD patients with an SABA (20 µg of inhaled procaterol) versus a placebo. The percentage of regional lung sound energy [quantitative lung data (QLD)] was evaluated with VRI. VRI, spirometry, and impulse oscillometry (IOS) were performed immediately before and 30 min after SABA administration.
RESULTS:
Ten male patients (69.6 ± 14.2 years of age, percentage predicted forced expiratory volume in 1 s: 43.8 ± 16.9%) were evaluated. The use of an SABA produced significant functional improvements in the spirometric and IOS measurements. Among the homogeneous emphysema patients (n = 7), the upper-lung QLD decreased (from 24.2 ± 5.8 to 18.8 ± 6.1%, p < 0.05) and the lower-lung QLD increased (from 37.9 ± 12.7 to 46.1 ± 14.3%, p < 0.05) following SABA inhalation. However, the significant redistribution of the regional lung QLD to the lower-lung field was not observed in 2 of the 3 inhomogeneous emphysema patients.
CONCLUSION:
The additional use of an SABA by COPD patients improved their pulmonary function, which was accompanied by changes in regional lung air flow. The distribution of emphysematous lesions and the bronchial reactivity to SABA appeared to affect the redistribution of the lung sounds following bronchodilator administration.
AuthorsMasamichi Mineshita, Shin Matsuoka, Teruomi Miyazawa
JournalRespiration; international review of thoracic diseases (Respiration) Vol. 87 Issue 1 Pg. 45-53 ( 2014) ISSN: 1423-0356 [Electronic] Switzerland
PMID23860295 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 S. Karger AG, Basel.
Chemical References
  • Bronchodilator Agents
  • Scopolamine Derivatives
  • Salmeterol Xinafoate
  • Theophylline
  • Albuterol
  • Tiotropium Bromide
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Albuterol (analogs & derivatives, therapeutic use)
  • Bronchodilator Agents (therapeutic use)
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Humans
  • Lung (diagnostic imaging, physiopathology)
  • Male
  • Middle Aged
  • Pulmonary Disease, Chronic Obstructive (diagnostic imaging, drug therapy, physiopathology)
  • Respiratory Sounds (physiopathology)
  • Salmeterol Xinafoate
  • Scopolamine Derivatives (therapeutic use)
  • Theophylline (therapeutic use)
  • Tiotropium Bromide
  • Tomography, X-Ray Computed
  • Vibration

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: