Photoletter to the editor - Calciphylaxis: a diagnostic and therapeutic challenge.

Abstract

Calciphylaxis is an uncommon necrotizing dermal condition, most often related to end-stage renal disease, associated with secondary hyperparathyroidism. The incidence is 1-4% per year in dialyzed patients. The condition is characterized by microcalcification of small and medium-sized blood vessels, causing cutaneous and soft tissue necrosis. The etiology of calciphylaxis is poorly understood, although many reports highlight the abnormal calcium-phosphate products as an important etiological factor. Calciphylaxis is associated with significant morbidity and mortality with estimated 5-year survival rates of less than 50%. Sepsis is the main cause of death. We report two patients of calciphylaxis treated with surgical debridement and excellent outcome in both cases.

• Authors: Hugo Marques Barreiros, João Goulão, Henriqueta Cunha, Elvira Bártolo
• Journal: Journal of dermatological case reports (J Dermatol Case Rep) Vol. 7 Issue 2 Pg. 69-70 (Jun 30 2013) ISSN: 1898-7249 [Print] Poland
• PMID: 23858346 (Publication Type: Journal Article)