Abstract | INTRODUCTION: The aim of this study was to determine the antimicrobial susceptibility of Neisseria gonorrhoeae isolates obtained from patients attending a public referral center for sexually transmitted diseases and specialized care services (STD/SCS) in Belo Horizonte, Brazil. METHODS: RESULTS: The specimens were 100% sensitive to cefixime, ceftriaxone and spectinomycin and exhibited resistances of 4.5% (9/201), 21.4% (43/201), 11.9% (24/201), 22.4% (45/201) and 32.3% (65/201) to azithromycin, ciprofloxacin, chloramphenicol, penicillin and tetracycline, respectively. Intermediate sensitivities of 17.9% (36/201), 4% (8/201), 16.9% (34/201), 71.1% (143/201) and 22.9% (46/201) were observed for azithromycin, ciprofloxacin, chloramphenicol, penicillin and tetracycline, respectively. The specimens had plasmid-mediated resistance to penicillin PPNG 14.5% (29/201) and tetracycline TRNG 11.5% (23/201). CONCLUSIONS: The high percentage of detected resistance to penicillin, tetracycline, chloramphenicol and ciprofloxacin indicates that these antibiotics are not appropriate for gonorrhea treatment at the Health Clinic and possibly in Belo Horizonte. The resistance and intermediate sensitivity of these isolates indicates that caution is recommended in the use of azithromycin and emphasizes the need to establish mechanisms for the surveillance of antimicrobial resistance for the effective control of gonorrhea.
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Authors | Lígia Maria Bedeschi Costa, Enio Roberto Pietra Pedroso, Virgílio Vieira Neto, Viviane Cata Preta Souza, Maria Juliana Bastos Teixeira |
Journal | Revista da Sociedade Brasileira de Medicina Tropical
(Rev Soc Bras Med Trop)
2013 May-Jun
Vol. 46
Issue 3
Pg. 304-9
ISSN: 1678-9849 [Electronic] Brazil |
PMID | 23856869
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Anti-Bacterial Agents
(pharmacology)
- Cross-Sectional Studies
- Female
- Gonorrhea
(epidemiology, microbiology)
- Humans
- Male
- Microbial Sensitivity Tests
- Middle Aged
- Neisseria gonorrhoeae
(drug effects, genetics, isolation & purification)
- Phenotype
- Young Adult
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