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Sirtuins as therapeutic targets of ALS.

Abstract
Sirtuins have received a lot of attention in biological functions associated with metabolism, survival development, and most recently, neurodegeneration. The versatile role of sirtuins can be readily redirected for drug discovery studies for novel treatment in amyotrophic lateral sclerosis (ALS), as presented in this highlight, by sirtuin-mediated ketogenic responses influencing mitochondrial function.
AuthorsGiulio Maria Pasinetti, Amanda E Bilski, Wei Zhao
JournalCell research (Cell Res) Vol. 23 Issue 9 Pg. 1073-4 (Sep 2013) ISSN: 1748-7838 [Electronic] England
PMID23856645 (Publication Type: Journal Article)
Chemical References
  • Enzyme Inhibitors
  • Stilbenes
  • Sirtuins
  • Resveratrol
Topics
  • Amyotrophic Lateral Sclerosis (drug therapy, metabolism)
  • Animals
  • Cell Nucleus (metabolism)
  • Cytoplasm (metabolism)
  • Enzyme Inhibitors (pharmacology)
  • Humans
  • Mice
  • Mitochondria (metabolism)
  • Resveratrol
  • Sirtuins (drug effects, metabolism)
  • Stilbenes (pharmacology)

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