Abstract | BACKGROUND: Immune responses to lung-associated self-antigens (SAgs) have been implicated in chronic lung allograft rejection. The goals of this study were to determine the prevalence of pre-existing antibodies (Abs) to the SAgs in pulmonary diseases and the association between pre-existing Abs to SAgs and the development of primary graft dysfunction ( PGD), donor-specific antibodies (DSA), and chronic rejection. METHODS: RESULTS: The overall prevalence of Abs to SAgs was 22.71%, including 18% in chronic obstructive pulmonary disease (p = 0.033), 34% in IPF (p = 0.0006), 29% in CF (p = 0.0023), and 19.6% in other diagnoses (p = 0.044). The incidence of PGD (88% vs 54%, p < 0.05), DSA (70% vs 45%, p < 0.01), and BOS (90% vs 38% (p < 0.001) after LTx was significantly higher in patients with pre-LTx Abs to SAgs than without. Pro-inflammatory cytokines ( interleukin-1β, interleukin-17, and interferon-γ) were elevated in patients who had pre-LTx Abs to SAgs, along with a reduction in anti-inflammatory interleukin-10. CONCLUSIONS: Patients with IPF and CF have the highest prevalence of Abs to SAgs. Patients with pre-existing Abs to SAgs are at increased risk for development of PGD, DSA, and BOS. Strategies to remove pre-existing Abs to SAgs should be considered to improve lung allograft outcome.
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Authors | Venkataswarup Tiriveedhi, Baskaran Gautam, Nayan J Sarma, Medhat Askar, Marie Budev, Aviva Aloush, Ramsey Hachem, Elbert Trulock, Bryan Myers, Alexander G Patterson, Thalachallour Mohanakumar |
Journal | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
(J Heart Lung Transplant)
Vol. 32
Issue 8
Pg. 807-14
(Aug 2013)
ISSN: 1557-3117 [Electronic] United States |
PMID | 23856218
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2013 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antibodies
- Autoantigens
- Collagen Type V
- Tubulin
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Topics |
- Antibodies
(blood)
- Autoantigens
(immunology)
- Collagen Type V
(immunology)
- Female
- Graft Rejection
(immunology)
- Humans
- Lung Transplantation
- Male
- Middle Aged
- Preoperative Care
- Primary Graft Dysfunction
(immunology)
- Tissue Donors
- Tubulin
(immunology)
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