HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Resveratrol and its metabolites modulate cytokine-mediated induction of eotaxin-1 in human pulmonary artery endothelial cells.

Abstract
Coronary heart disease (CHD) is a leading cause of death in many developed countries. Evidence has long implicated endothelial injury and inflammation as apical events in the pathogenesis of atherosclerosis, the primary cause of CHD. Numerous risk factors contribute to a damaged, inflamed endothelium. Conversely, cardioprotective agents targeting the dysfunctional endothelium have also been identified, notably from dietary sources. We have used cultured human pulmonary artery endothelial cells (HPAECs) to test the diet-mediated cardioprotective hypothesis. In this review, we summarize our recent findings on control of transcription and expression of inflammation biomarker eotaxin-1 in HPAECs exposed to single or combined proinflammatory cytokines interleukin-13 (IL-13) and tumor necrosis factor-α (TNF-α), and attenuation of the observed eotaxin-1 responses by prior or simultaneous treatment with resveratrol and its metabolites. Control of eotaxin-1 gene regulation may be considered an in vitro model to evaluate agents linking cardioprotection with endothelial cell damage and inflammation.
AuthorsJoseph M Wu, Tze-chen Hsieh, Ching-Jen Yang, Susan C Olson
JournalAnnals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1290 Pg. 30-6 (Jul 2013) ISSN: 1749-6632 [Electronic] United States
PMID23855463 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Copyright© 2013 New York Academy of Sciences.
Chemical References
  • Chemokine CCL11
  • Cytokines
  • Inflammation Mediators
  • Stilbenes
  • Resveratrol
Topics
  • Chemokine CCL11 (biosynthesis)
  • Cytokines (physiology)
  • Endothelial Cells (drug effects, metabolism)
  • Humans
  • Inflammation Mediators (physiology)
  • Pulmonary Artery (drug effects, metabolism)
  • Resveratrol
  • Stilbenes (metabolism, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: