Abstract | CONTEXT:
Gynecomastia, defined as benign proliferation of glandular breast tissue has a prevalence of 32% to 72% in the male. In the urology setting, it is associated to patients with prostate cancer and hormone treatment with a prevalence of 15% in the case of complete hormone blockage and 75% in monotherapy. The different options of treatment in prostate cancer have changed in recent decades. Thus, we have focused on this subject to evaluate the different therapy options of hormone manipulation induced gynecomastia in prostate cancer patients. OBJECTIVE: ACQUISITION OF EVIDENCE: Using the PICO type structured search strategy (Patient or problem, Intervention, Comparison, Outcome or result) in the data bases of PubMed-Medline and Cochrane, identification was made of the relevant studies related to the treatment of gynecomastia in Prostate Cancer patients treated with nonsteroidal antiandrogens. SYNTHESIS OF EVIDENCE: We have found 3 possible therapeutic options for the treatment of gynecomastia and mastodynia in patients with hormone deprivation therapy for prostate cancer. The 10Gy radiotherapy would be an option for the treatment of gynecomastia, although not all the patients need prophylactic treatment since only 50% report moderate-severe discomfort. Another option is the use of drugs such as tamoxifen 20mg/day that lead to a significant decrease in the mammary effects. CONCLUSIONS:
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Authors | C Bautista-Vidal, O Barnoiu, E García-Galisteo, P Gómez-Lechuga, V Baena-González |
Journal | Actas urologicas espanolas
(Actas Urol Esp)
2014 Jan-Feb
Vol. 38
Issue 1
Pg. 34-40
ISSN: 1699-7980 [Electronic] Spain |
PMID | 23850393
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2012 AEU. Published by Elsevier Espana. All rights reserved. |
Chemical References |
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Topics |
- Androgen Antagonists
(adverse effects, therapeutic use)
- Gynecomastia
(chemically induced, therapy)
- Humans
- Male
- Prostatic Neoplasms
(drug therapy)
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