Abstract | BACKGROUND: METHODS: Patients with histologically confirmed oral leukoplakia received a single treatment of ALA PDT in cohorts with escalating doses of light (585nm). Clinical, histologic, and biologic markers were assessed. RESULTS: Analysis of 11 participants is reported. No significant toxicity from ALA PDT was observed in patients who received ALA with a light dose of up to 4J/cm(2). One participant experienced transient grade 3 transaminase elevation due to ALA. One participant had a partial clinical response 3months after treatment. Biologic mucosal risk markers showed no significant associations. Determination of MTD could not be accomplished within a feasible timeframe for completion of the study. CONCLUSIONS: ALA PDT could be safely administered with a light dose up to 4J/cm(2) and demonstrated activity. Larger studies are needed to fully elucidate the MTD and efficacy of ALA- PDT.
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Authors | Stuart J Wong, Bruce Campbell, Becky Massey, Denis P Lynch, Ezra E W Cohen, Elizabeth Blair, Rebecca Selle, Julia Shklovskaya, Borko D Jovanovic, Silvia Skripkauskas, Alexander Dew, Peter Kulesza, Vamsi Parimi, Raymond C Bergan, Eva Szabo |
Journal | Oral oncology
(Oral Oncol)
Vol. 49
Issue 9
Pg. 970-976
(Sep 2013)
ISSN: 1879-0593 [Electronic] England |
PMID | 23845699
(Publication Type: Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- Photosensitizing Agents
- Aminolevulinic Acid
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Topics |
- Aminolevulinic Acid
(therapeutic use)
- Humans
- Leukoplakia, Oral
(drug therapy)
- Photochemotherapy
- Photosensitizing Agents
(therapeutic use)
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