The effect of ipsapirone on behavioural and cardiac responses in the shock-probe/defensive burying test in male rats.

Abstract

The effects of the 5-HT1A receptor agonist, ipsapirone, on cardiac and behavioural responses of male Wistar rats in a conditioned defensive burying paradigm for anxiolytics were investigated. The shocked rats displayed defensive burying accompanied by an increase in heart rate. Ipsapirone-treated rats (5 and 10 mg/kg i.p.) showed less burying behaviour than did vehicle-treated controls, and the tachycardiac response was also reduced in a dose-dependent way whereas eating behaviour was facilitated. The results demonstrate the effectiveness of ipsapirone, thereby suggesting the involvement of 5-HT1A receptors in a conditioned anxiety situation that elicits an active coping behaviour and sympathetic activation.

• Authors: S M Korte, B Bohus
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 181 Issue 3 Pg. 307-10 (Jun 08 1990) ISSN: 0014-2999 [Print] Netherlands
• PMID: 2384138 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Pyrimidines
• ipsapirone

Topics

• Animals
• Behavior, Animal (drug effects)
• Conditioning, Operant (drug effects)
• Electrocardiography
• Electroshock
• Heart (drug effects)
• Male
• Pyrimidines (pharmacology)
• Rats
• Rats, Inbred Strains