Abstract | INTRODUCTION: Prophylaxis with plasma-derived or recombinant activated factor VII is beneficial in severe factor VII deficiency. To understand why prophylactic treatment with both products is efficacious, we conducted a pharmacokinetic study. MATERIALS AND METHODS: RESULTS: CONCLUSIONS:
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Authors | Natascha C J Mathijssen, Rosalinde Masereeuw, Pal Andre Holme, Marian G J van Kraaij, Britta A P Laros-van Gorkom, Flora Peyvandi, Waander L van Heerde |
Journal | Thrombosis research
(Thromb Res)
Vol. 132
Issue 2
Pg. 256-62
(Aug 2013)
ISSN: 1879-2472 [Electronic] United States |
PMID | 23834817
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Recombinant Proteins
- Factor VIIa
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Topics |
- Adult
- Blood Coagulation Tests
- Cross-Over Studies
- Factor VII Deficiency
(blood, drug therapy)
- Factor VIIa
(pharmacokinetics, therapeutic use)
- Female
- Half-Life
- Hemostasis
- Humans
- Male
- Middle Aged
- Recombinant Proteins
(blood, pharmacokinetics, therapeutic use)
- Young Adult
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