Persistence of yellow fever vaccine-induced antibodies after solid organ transplantation.

Abstract

Immunization using live attenuated vaccines represents a contra-indication after solid organ transplantation (SOT): consequently, transplant candidates planning to travel in countries where yellow fever is endemic should be vaccinated prior to transplantation. The persistence of yellow fever vaccine-induced antibodies after transplantation has not been studied yet. We measured yellow-fever neutralizing antibodies in 53 SOT recipients vaccinated prior to transplantation (including 29 kidney recipients and 18 liver recipients). All but one (98%) had protective titers of antibodies after a median duration of 3 years (min.: 0.8, max.: 21) after transplantation. The median antibody level was 40 U/L (interquartile range: 40-80). For the 46 patients with a known or estimated date of vaccination, yellow-fever antibodies were still detectable after a median time of 13 years (range: 2-32 years) post-immunization. Our data suggest there is long-term persistence of antibodies to yellow fever in SOT recipients who have been vaccinated prior to transplantation.

• Authors: B Wyplosz, C Burdet, H François, A Durrbach, J C Duclos-Vallée, M-F Mamzer-Bruneel, P Poujol, O Launay, D Samuel, D Vittecoq, P H Consigny, GEVACCIM
• Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Am J Transplant) Vol. 13 Issue 9 Pg. 2458-61 (Sep 2013) ISSN: 1600-6143 [Electronic] United States
• PMID: 23834702 (Publication Type: Journal Article)
• Copyright: © Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons.

Chemical References

• Antibodies, Viral
• Yellow Fever Vaccine

Topics

• Antibodies, Viral (analysis)
• Humans
• Kidney Transplantation
• Liver Transplantation
• Prospective Studies
• Transplantation Immunology
• Yellow Fever Vaccine (immunology)