[Protective effect of anti-hypoxia shenggui tablet on cerebral ischemia injure].

Abstract

OBJECTIVE:

To investigate the protective effects of Shengui tablet (Chinese Traditional Medicine) on experimental cerebral ischemia by acute cerebral ischemia hypoxia in mice and bilateral ligation of the carotid artery in rats.

METHODS:

In the acute cerebral ischemia hypoxia model, the mice were randomly divided into control group, low-, middle- and high-dose (0.16, 0.33 and 1.00 g/kg) groups of Shengui tablet, after oral treatment for 30 d, gasping time of isolated heads of mice were observed. In bilateral ligation of the carotid artery cerebral ischemia model, the rats were randomly divided into control group, model group and low-, middle-, high-dose (0.072, 0.149 and 0.450 g/kg) groups of Shengui tablet. After oral treatment for 7 d, the cerebral index, superoxide dismutase (SOD) activity and the content of malondialdehyde (MDA) were measured.

RESULTS:

Compared with the control model, Shengui tablet middle- and high-dose could significantly prolong gasping time of isolate heads of mice. Compared with model group, Shengui tablet low-, middle- and high-dose could significantly decrease the cerebral index and enhance SOD activity in brain tissue; only high-dose could reduce the content of MDA.

CONCLUSION:

Shengui tablet has significant protective effect on the cerebral ischemia.

• Authors: Yong-Ping Shi, Hui Wang, Huai-Xin Wang, Jin-Da Wang, Ru-Huan Wang, Yan-Fang Zhang, Wen-Yu Cui, Lian Duan, Hai Wang
• Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (Zhongguo Ying Yong Sheng Li Xue Za Zhi) Vol. 29 Issue 2 Pg. 139-41, 146 (Mar 2013) ISSN: 1000-6834 [Print] China
• PMID: 23833968 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Neuroprotective Agents
• Malondialdehyde
• Superoxide Dismutase

Topics

• Animals
• Brain (metabolism)
• Brain Ischemia (metabolism, prevention & control)
• Drugs, Chinese Herbal (pharmacology)
• Female
• Male
• Malondialdehyde (metabolism)
• Mice
• Mice, Inbred Strains
• Neuroprotective Agents (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Superoxide Dismutase (metabolism)