[Salicylic acid derivatives as simplified and novel GK small molecule activators].

Abstract

Glucokinase (GK) is a new target for the treatment of type II diabetes mellitus (T2DM). In order to find a structure-simplified small molecule GK activator, 19 salicylic acid derivatives were designed and synthesized based on new lead compound (1). Experimental results showed that the potency of compound 8h is superior to control RO-28-0450 in GK activation.

• Authors: Lian-Chao Huo, Yu-Liang Zhang, Lei Lei, Shuai-Nan Liu, Zhu-Fang Shen, Yu-Ling Wang, Hong-Rui Song, Zhi-Qiang Feng
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 48 Issue 4 Pg. 514-20 (Apr 2013) ISSN: 0513-4870 [Print] China
• PMID: 23833938 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Enzyme Activators
• Hypoglycemic Agents
• RO-28-0450
• Salicylates
• Thiazoles
• Glucokinase

Topics

• Drug Design
• Enzyme Activation (drug effects)
• Enzyme Activators (chemical synthesis, chemistry, pharmacology)
• Glucokinase (metabolism)
• Hypoglycemic Agents (chemical synthesis, chemistry, pharmacology)
• Molecular Structure
• Salicylates (chemical synthesis, chemistry, pharmacology)
• Thiazoles (pharmacology)