Agarofuran sesquiterpenes from Schaefferia argentinensis.

Abstract

Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from the aerial parts of Schaefferia argentinensis Speg. Their structures were determined by a combination of 1D and 2D NMR and MS techniques. The in vitro antiproliferative activity of the major sesquiterpenes was examined in T47D, MCF7, and MDA-MB231 human cancer cell lines, but was found to be marginal.

• Authors: Manuela E García, Rubén D Motrich, Beatriz L Caputto, Marianela Sánchez, Jorge A Palermo, Ana Estévez-Braun, Angel G Ravelo, Viviana E Nicotra
• Journal: Phytochemistry (Phytochemistry) Vol. 94 Pg. 260-7 (Oct 2013) ISSN: 1873-3700 [Electronic] England
• PMID: 23827326 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Sesquiterpenes
• dihydroagarofuran

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Celastraceae (chemistry)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Humans
• MCF-7 Cells
• Magnetic Resonance Spectroscopy
• Mass Spectrometry (methods)
• Molecular Structure
• Plant Components, Aerial (chemistry)
• Sesquiterpenes (chemistry, isolation & purification, pharmacology)