[Efficacy of radiotherapy for adult patients with Langerhans cell histiocytosis].

Abstract

OBJECTIVE:

To analyze efficacy of radiotherapy for adult patients with Langerhans cell histiocytosis (LCH).

METHODS:

Clinical features and efficacy of radiotherapy for biopsy-proven adult patient with LCH from January 2000 to October 2012 in our hospital were retrospectively analyzed.

RESULTS:

Seventeen (11 male and 6 female) adult LCH patients with a mean age of 31 (18-56) years old were treated by irradiation, all patients presented as single-system disease. The mean duration from diagnosis to irradiation was 8.3 (0-108) months. Although 12 of 17 patients (70.6%) had short-term response to radiotherapy, all patients but one (94.1%) progressed during long-term follow-up, the mean progression-free survival (PFS) was 14 (0-131) months. Of the progressed patients, one relapsed in situ, the remaining 15 patients progressed outside the irradiated region. Thirteen patients (76.5%) eventually progressed to multisystem disease.

CONCLUSION:

Though radiotherapy for LCH in adults produced a high short-term response up to 70.6%, most of patients eventually progressed in situ or outside the irradiation region during long-term follow-up.

• Authors: Ming-hui Duan, Xiao Han, Jian Li, Bing Han, Wei Zhang, Tie-nan Zhu, Jun-ling Zhuang, Dao-bin Zhou
• Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi (Zhonghua Xue Ye Xue Za Zhi) Vol. 34 Issue 6 Pg. 482-4 (Jun 2013) ISSN: 0253-2727 [Print] China
• PMID: 23827101 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Adult
• Disease Progression
• Disease-Free Survival
• Female
• Histiocytosis, Langerhans-Cell (radiotherapy)
• Humans
• Male
• Middle Aged
• Retrospective Studies
• Treatment Outcome
• Young Adult