Abstract | OBJECTIVE AND BACKGROUND: MATERIAL AND METHODS: RESULTS: Significant differences (P=0.001) were detected in p21 ras protein expression between the three groups. A near 2-fold increase in p21 ras staining was observed in the cirrhotic cases compared to the hepatitis cases, and p21 ras expression was decreased in the HCC group. p21 ras expression correlated with stage (r=0.64, P=0.001) and grade (r=(-)0.65, P=0.001) in the HCC group and grade in the HCV group (r=0.44, P=0.008). Both p21 ras expression and TUNEL-LI were significantly lower in large HCCs compared to small HCCs (P=0.01 each). The TUNEL values were negatively correlated with stage in the HCC group (r=(-)0.85, P=0.001). The TUNEL values were also negatively correlated with grade in both the HCV and HCC groups (r=0.89, P=0.001 and r=(-)0.53, P=0.001, respectively). The p21 ras scores were significantly correlated with the TUNEL-LI values in the HCC group (r=0.63, P=0.001) and HCV group (r=0.88, P=0.001). CONCLUSIONS:
p21 ras acts as an initiator in HCC complicating type 4 chronic HCV and is downregulated with HCC progression, which most likely promotes tumor cell survival because it facilitates the downregulation of apoptosis with tumor progression.
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Authors | Nahed Baddour, Ebtehal Farrag, Ahmed Zeid, Essam Bedewy, Yousry Taher |
Journal | Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
(Chin J Cancer Res)
Vol. 25
Issue 3
Pg. 281-8
(Jun 2013)
ISSN: 1000-9604 [Print] China |
PMID | 23825904
(Publication Type: Journal Article)
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