Abstract |
The present study aimed to gain more insight in the social behavioral phenotype, and related autistic symptomatology, of children with an extra X chromosome in comparison to children with ASD. Participants included 60 children with an extra X chromosome (34 boys with Klinefelter syndrome and 26 girls with Trisomy X), 58 children with ASD and 106 controls, aged 9 to 18 years. We used the Autism Diagnostic Interview, Social Responsiveness Scale, Social Anxiety Scale and Social Skills Rating System. In the extra X group, levels of social dysfunction and autism symptoms were increased, being in between controls and ASD. In contrast to the ASD group, the extra X group showed increased social anxiety. The effects were similar for boys and girls with an extra X chromosome.
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Authors | Sophie van Rijn, Lex Stockmann, Martine Borghgraef, Hilgo Bruining, Conny van Ravenswaaij-Arts, Lutgarde Govaerts, Kerstin Hansson, Hanna Swaab |
Journal | Journal of autism and developmental disorders
(J Autism Dev Disord)
Vol. 44
Issue 2
Pg. 310-20
(Feb 2014)
ISSN: 1573-3432 [Electronic] United States |
PMID | 23824705
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Case-Control Studies
- Child
- Child Development Disorders, Pervasive
(diagnosis, psychology)
- Chromosomes, Human, X
- Female
- Humans
- Klinefelter Syndrome
(diagnosis, psychology)
- Male
- Phenotype
- Sex Chromosome Aberrations
- Sex Chromosome Disorders of Sex Development
(diagnosis, psychology)
- Social Behavior
- Trisomy
(diagnosis)
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