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The social behavioral phenotype in boys and girls with an extra X chromosome (Klinefelter syndrome and Trisomy X): a comparison with autism spectrum disorder.

Abstract
The present study aimed to gain more insight in the social behavioral phenotype, and related autistic symptomatology, of children with an extra X chromosome in comparison to children with ASD. Participants included 60 children with an extra X chromosome (34 boys with Klinefelter syndrome and 26 girls with Trisomy X), 58 children with ASD and 106 controls, aged 9 to 18 years. We used the Autism Diagnostic Interview, Social Responsiveness Scale, Social Anxiety Scale and Social Skills Rating System. In the extra X group, levels of social dysfunction and autism symptoms were increased, being in between controls and ASD. In contrast to the ASD group, the extra X group showed increased social anxiety. The effects were similar for boys and girls with an extra X chromosome.
AuthorsSophie van Rijn, Lex Stockmann, Martine Borghgraef, Hilgo Bruining, Conny van Ravenswaaij-Arts, Lutgarde Govaerts, Kerstin Hansson, Hanna Swaab
JournalJournal of autism and developmental disorders (J Autism Dev Disord) Vol. 44 Issue 2 Pg. 310-20 (Feb 2014) ISSN: 1573-3432 [Electronic] United States
PMID23824705 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adolescent
  • Case-Control Studies
  • Child
  • Child Development Disorders, Pervasive (diagnosis, psychology)
  • Chromosomes, Human, X
  • Female
  • Humans
  • Klinefelter Syndrome (diagnosis, psychology)
  • Male
  • Phenotype
  • Sex Chromosome Aberrations
  • Sex Chromosome Disorders of Sex Development (diagnosis, psychology)
  • Social Behavior
  • Trisomy (diagnosis)

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