Abstract | BACKGROUND: METHODS: This was a randomized, placebo-controlled pilot trial. One hundred and twenty-four patients scheduled for ERCP from December 2008 to May 2010 randomly received one of the following three interventions: pre-ERCP somatostatin (0.5 mg/h for 24 hours, starting 1 hour prior to ERCP; n = 36), post-ERCP somatostatin (0.5 mg/h for 24 hours, starting 1 hour after ERCP; n = 47), or placebo (saline for 24 hours, starting 1 hour prior to ERCP; n = 41). Serum amylase and lipase concentrations were measured 1 to 3 hours prior to ERCP and 6, 24, and 48 hours after ERCP. RESULTS: The three groups did not differ in age, gender, medical history, or ERCP procedure (catheterization using contrast or guidewire, pancreatic duct visualization, procedure time, or procedure type). The rate of PEP was 13.7% (17/124) in the overall study sample and 16.7% (6/36), 10.6% (5/47), and 14.6% (6/41) in the pre-ERCP somatostatin, post-ERCP somatostatin, and placebo groups, respectively (P = 0.715). The rate of post-ERCP hyperamylasemia was 19.4% (7/36), 21.3% (10/47), and 46.3% (19/41) in the pre-ERCP somatostatin, post-ERCP somatostatin, and placebo groups, respectively (P = 0.011). CONCLUSIONS: High-dose, long-term continuous infusion (0.5 mg/h for 24 hours) of somatostatin, performed as either a pre- or post-ERCP, can reduce the incidence of hyperamylasemia, but not PEP.
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Authors | Zi-kai Wang, Yun-sheng Yang, Feng-chun Cai, Yong-hua Wang, Xiao-lin Shi, Chen Ding, Wen Li |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 126
Issue 13
Pg. 2403-8
(Jul 2013)
ISSN: 2542-5641 [Electronic] China |
PMID | 23823808
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Aged
- Cholangiopancreatography, Endoscopic Retrograde
(adverse effects)
- Female
- Humans
- Hyperamylasemia
(prevention & control)
- Male
- Middle Aged
- Pancreatitis
(prevention & control)
- Pilot Projects
- Somatostatin
(therapeutic use)
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