[Evaluation of the efficacy and tolerance of ibandronic acid in patients with osteoarthrosis in the knee joints concurrent with osteoporosis: a pilot study].

Abstract

AIM:

To evaluate the efficacy and tolerance of ibandronic acid (bonviva) in patients with osteoporosis (OP) concurrent with osteoarthrosis (OA) in the knee joints (KJ).

SUBJECTS AND METHODS:

Twenty female outpatients aged 56 to 77 years with postmonopausal OP and primary KJ OA were examined. All the patients took bonviva in a dose of 150 mg monthly during a year.

RESULTS:

During the treatment, the patients showed a significant reduction in the values of all components of the Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) (pain intensity from 51.7 +/- 11.6 to 34.6 +/- 20.7 mm, stiffness from 96.0 +/- 55.6 to 78.5 +/- 46.6 mm, and functional failure from 783.6 +/- 333.2 to 657.8 +/- 360.9 mm according to a visual analogue scale), the Oswestry disability index, as well as in the concentration of markers for bone resorption and cartilage degradation. The need for nonsteroidal anti-inflammatory drugs was stated to decrease.

CONCLUSION:

Bonviva therapy results in a significant reduction in pain, KJ stiffness, and locomotor functional failure in patients with gonoarthrosis.

• Authors: L I Alekseeva, E M Zaitseva, E P Sharapova, E A Taskina, A V Smirnov, N V Demin, E N Aleksandrova
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 85 Issue 5 Pg. 30-6 ( 2013) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 23819336 (Publication Type: Journal Article)

Chemical References

• Bone Density Conservation Agents
• Diphosphonates
• Ibandronic Acid

Topics

• Aged
• Bone Density Conservation Agents (adverse effects, therapeutic use)
• Bone Resorption (drug therapy)
• Cartilage (pathology)
• Diphosphonates (adverse effects, therapeutic use)
• Disability Evaluation
• Female
• Humans
• Ibandronic Acid
• Locomotion (drug effects)
• Middle Aged
• Osteoarthritis, Knee (complications, drug therapy, physiopathology)
• Osteoporosis, Postmenopausal (complications, drug therapy, pathology)
• Pain (drug therapy, etiology)
• Pain Measurement
• Pilot Projects
• Severity of Illness Index