Anti-rPru p 3 IgE levels are inversely related to the age at onset of peach-induced severe symptoms reported by peach-allergic adults.

Abstract

Sensitisation to peach lipid transfer protein (LTP; Pru p 3) is significantly associated with severe allergic symptoms in adults, but little is known about the age at onset of peach allergy. We investigated a possible correlation between specific IgE levels to Pru p 3 and the age at onset of peach allergy. One hundred and forty-eight patients allergic to peach were divided into 6 classes according to the age at onset. Sera were analyzed for IgE antibodies to peach, rPru p 3, rPru p 1, rPru p 4, rBet v 1, rBet v 2, total IgE titre, and tryptase; all collected data were statistically analysed. A significant inverse correlation was found between the age at onset of peach allergy and anti-rPru p 3 IgE levels at diagnosis (p < 0.0005; Spearman's ρ = -0.3833). In contrast, the age at onset was directly correlated with both anti-rPru p 1 IgE levels (p = 0.0001; Spearman's ρ = 0.3197) and anti-rBet v 1 IgE levels (p = 0.0006; Spearman's ρ = 0.2914) at diagnosis. No correlations were detected between the reported age at onset and anti-peach, anti-rPru p 4, anti-rBet v 2 IgE and total IgE values and serum tryptase levels. At diagnosis, when peach allergy starts at a younger age, it is likely associated with Pru p 3 sensitisation, and the younger the onset, the higher the IgE titres. When peach allergy starts at an older age, it is more likely the result of cross-reactivity to Bet v1.

• Authors: Elide Anna Pastorello, Laura Farioli, Chrysi Stafylaraki, Ambra Mascheri, Joseph Scibilia, Valerio Pravettoni, Laura Primavesi, Marta Piantanida, Michele Nichelatti, Riccardo Asero
• Journal: International archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 162 Issue 1 Pg. 45-9 ( 2013) ISSN: 1423-0097 [Electronic] Switzerland
• PMID: 23817315 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 S. Karger AG, Basel.

Chemical References

• Antibodies, Anti-Idiotypic
• Antigens, Plant
• Plant Proteins
• Pru p 3 allergen
• anti-IgE antibodies
• Immunoglobulin E

Topics

• Adolescent
• Adult
• Age of Onset
• Antibodies, Anti-Idiotypic
• Antigens, Plant (immunology)
• Female
• Food Hypersensitivity (immunology)
• Humans
• Immunoglobulin E
• Male
• Middle Aged
• Plant Proteins (immunology)
• Prunus