HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Abundant REM sleep in a patient with Alzheimer's disease.

Abstract
In patients with Alzheimer's disease (AD), greatly diminished REM sleep might be expected because of the cholinergic deficit in this disease and because cholinergic agonists stimulate REM sleep in humans and animals. We present here an unusual case of neuropathologically verified AD with abundant REM sleep. We suggest 4 possible explanations for this phenomenon: (1) selective cell loss in caudal midbrain/rostral pontine structures known to control sleep; (2) development of narcolepsy; (3) unrecognized affective disorder; (4) disruption of circadian timekeeping system.
AuthorsD L Bliwise, G Nino-Murcia, L S Forno, C Viseskul
JournalNeurology (Neurology) Vol. 40 Issue 8 Pg. 1281-4 (Aug 1990) ISSN: 0028-3878 [Print] United States
PMID2381539 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Topics
  • Aged
  • Alzheimer Disease (pathology, physiopathology)
  • Brain (pathology, physiopathology)
  • Electroencephalography
  • Electromyography
  • Humans
  • Male
  • Sleep, REM

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: