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Values of MMP-2 and MMP-9 in tumor tissue of basal-like breast cancer patients.

Abstract
Gelatinase A (MMP-2) and gelatinase B (MMP-9) are proteolytic enzymes involved in process of tumor invasion, and they are considered as possible tumor markers in breast cancer patients. In this study, we measured activity of latent and active form of MMP-2 and MMP-9 in tumor and adjacent tissue of 60 breast cancer patients by SDS-PAGE zymography. The activity of both form of gelatinases significantly increased with each advancing clinical stage of disease. ProMMP-9 and aMMP-9 activity in tumor tissue shows a positive association with tumor size. Patients with lymph node involvement have higher proMMP-2, aMMP-2 and aMMP-9 activity than node negative patients. Steroid receptor-negative tumors had enhanced aMMP-2 and aMMP-9 activity. Patients with basal-like cancers had higher proMMP-2 tumor activity and aMMP-2 adjacent tissue activity compared to patients with luminal A tumors. Patients with negative hormone receptors are associated with increased activity of both form of gelatinases in adjacent tissue. Reported increased activity of MMP-2 in tumor and adjacent tissue of basal-like tumors implicates that MMP-2 might have a role in aggressive biology of basal-like cancers. Additional investigations regarding molecular pathways in adjacent tissue could give better insight into aggressive nature of basal-like carcinomas.
AuthorsSandra Radenkovic, Gordana Konjevic, Vladimir Jurisic, Katarina Karadzic, Marina Nikitovic, Kristina Gopcevic
JournalCell biochemistry and biophysics (Cell Biochem Biophys) Vol. 68 Issue 1 Pg. 143-52 (Jan 2014) ISSN: 1559-0283 [Electronic] United States
PMID23812723 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • Enzyme Precursors
  • pro-matrix metalloproteinase 9
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (metabolism)
  • Breast Neoplasms (enzymology, pathology)
  • Enzyme Precursors (metabolism)
  • Female
  • Humans
  • Lymphatic Metastasis
  • Matrix Metalloproteinase 2 (metabolism)
  • Matrix Metalloproteinase 9 (metabolism)
  • Middle Aged
  • Neoplasm Staging

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